Sentinel surveillance systemsIntegrating Multiplex Serology into Sentinel Surveillance Systems in sub-Saharan Africa: A Pilot Study in Madagascar play a…
Sentinel surveillance systems play a central role in infectious disease monitoring through tracking syndromic patterns for priority conditions at strategically selected clinical sites. However, as these systems capture symptomatic infections, they represent an incomplete view of population exposure and risk. We propose the integration of serological surveillance using multiplex bead assays (MBAs) into existing sentinel workflows in sub-Saharan Africa to expand the scope of these systems. Integrated serosurveillance would enable sentinel systems to identify immunity gaps, evaluate the progress of public health interventions, and inform risk assessments for future outbreaks. Using the example of a pilot studybiological sentinel surveillance system in Madagascar, we outline how this integration can be achieved within established infrastructures. We further discuss key methodological and operational considerations and the coordinated action needed to move this approach toward broader implementation across the African context.








